The filamentation pathway controlled by the Efg1 regulator protein is required for normal biofilm formation and development inCandida albicans
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چکیده
منابع مشابه
Investigation the expression Candida albicans EFG1 gene in Vaginal Candidiasis and biofilm formation
Candida albicans has the ability to change between yeast and hyphal cells and is known to be a virulence property. Efg1gene of C.albicans is as a main transcription factor that plays pivotal roles in biofilm formation The aim of the current study is to investigate the presence of Efg1 gene in Candida albicans isolates from women with vaginal candidiasis and its impact on biofilm formation.We us...
متن کاملinvestigation the expression candida albicans efg1 gene in vaginal candidiasis and biofilm formation
candida albicans has the ability to change between yeast and hyphal cells and is known to be a virulence property. efg1gene of c.albicans is as a main transcription factor that plays pivotal roles in biofilm formation the aim of the current study is to investigate the presence of efg1 gene in candida albicans isolates from women with vaginal candidiasis and its impact on biofilm formation.we us...
متن کاملEfg1, a morphogenetic regulator in Candida albicans, is a sequence-specific DNA binding protein.
Efg1 is essential for hyphal development in the human pathogen Candida albicans under most conditions. Efg1 is related to basic helix-loop-helix regulators, and therefore most workers presume that Efg1 is a transcription factor. Here we confirm that Efg1 is a DNA binding protein that can interact specifically with the E box.
متن کاملThe APSES transcription factor Efg1 is a global regulator that controls morphogenesis and biofilm formation in Candida parapsilosis
Efg1 (a member of the APSES family) is an important regulator of hyphal growth and of the white-to-opaque transition in Candida albicans and very closely related species. We show that in Candida parapsilosis Efg1 is a major regulator of a different morphological switch at the colony level, from a concentric to smooth morphology. The rate of switching is at least 20-fold increased in an efg1 kno...
متن کاملThe Role of Candida albicans SPT20 in Filamentation, Biofilm Formation and Pathogenesis
Candida albicans is a ubiquitous fungus, which can cause very serious and sometimes life-threatening infections in susceptible patients. We used Caenorhabditis elegans as a model host to screen a library of C. albicans mutants for decreased virulence and identified SPT20 as important for virulence. The transcription co-activator SPT20 was identified originally as a suppressor of Ty and solo δ i...
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ژورنال
عنوان ژورنال: FEMS Microbiology Letters
سال: 2002
ISSN: 0378-1097,1574-6968
DOI: 10.1111/j.1574-6968.2002.tb11330.x